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KMID : 0897520080130010010
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Journal of Korean Association of Social Psychiatry
2008 Volume.13 No. 1 p.10 ~ p.16
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The Conversion Rates Difference to the Alzheimer Dementia between the Normal Elderly Group and the Mild Cognitive Impairment Group in One Community Cohort：18 Months’ Prospective Follow-up Study
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Kim Tae-Young
Ko Dae-Kwan
Shon Jee-Hoon
Kim Jin-Young
Lee Dong-Hyun
Jeon Hong-Jin
Chang Sung-Man
Lee You-Ra
Choi Ji-Hwan
Yoon Hyung-Kun
Cho Maeng-Je
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Abstract
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Objectives：The aim of this study is to compare the conversion rates to Alzheimer dementia between the normal elderly group and the mild cognitive impairment group at the community cohort.
Methods：Among the 229 nondemented elderly who had undergone the first wave in 2006, 70 subjects completed the second wave 18 months later. We used the Korean version of Mini Mental Status Exam(MMSE-K), the Korean version of the CERAD(Consortium to Establish a Registry for Alzheimer’s Disease) neuropsychological batteries, the Korean version of Geriatric Depression Scale, and the Instrumental Activities of Daily Living scale. Psychiatrists diagnosed mild cognitive impairment and Alzheimer dementia by Petersen criteria and Diagnostic and Statistical Manual of Mental Disorders fourth edition(DSM-IV) criteria. We used the multivariate logistic regression to calculate the odds ratio for the conversion to Alzheimer dementia between two groups.
Results：While only one subject converted to Alzheimer dementia among 43 normal elderly(2.3%), there were 5 Alzheimer dementia conversions out of 21 mild cognitive impairment cases(23.8%). The odds ratio between two groups is about 30. No other clinical variables predicted progression toward Alzheimer dementia.
Conclusion：The elderly with mild cognitive impairment has higher risk of conversion to Alzheimer dementia than the normal elderly in the community cohort.
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KEYWORD
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Mild cognitive impairment, Alzheimer dementia, Conversion
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